Code: 32120
3 x 12 ml R1 buffer; 3 x 4 ml R2 latex reagent
During plasma coagulation soluble fibrin is generated by the influence of thrombin on fibrinogen. The soluble fibrin is cross-linked to the vessel walls by factor XIIIa. When splitting this cross-linked fibrin, characteristic products called D-dimers are released.Increased D-dimer concentrations are found in thrombotic diseases and microthrombotic events (e.g. in case of disseminated intravascular coagulation, DIC). D-dimer determination is mainly used to exclude deep vein thrombosis of the leg and pulmonary embolism.
Particle enhanced immunoturbidimetric test.
Fixed time determination of the D-dimer concentration by photometric measurement of antigen-antibody-reaction between antibodies against D-dimer bound to particles and D-dimer present in the sample.