Dia-PROTEIN C

Code: 07108
4 x 2 ml
Dia-PROTEIN C
INTENDED USE
 
The Diagon Ltd Protein C assay is intended for the quantitative determination of protein C in human plasma using a chromogenic assay method. Protein C is a vitamin K dependent protein which plays an important role in the regulation of anticoagulant mechanisms. It can inhibit coagulation by inactivating factors Va1 and Vllla2 or, when activated, can stimulate fibrinolysis. Protein C circulates as a zymogen, and is converted to an active serine protease by the action of thrombin in the presence of thrombomodulin. Both hereditary and acquired Protein C deficiencies have been shown to be a risk factor for development of venous thrombosis. Protein C in plasma is activated by a specific fraction from the Agkistrodoncontortrix snake venom. The amount of activated protein C (APC) is determined by monitoring the rate of hydrolysis of a protein C specific chromogenic substrate. The release of pNA is measured at 405 nm and is proportional to the protein C level.